Examining Copper-dependent Cell Death-associated Genes in Relation to Immune Cell Presence and Disease Outcomes in Stomach Adenocarcinoma
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i1.3705
Abstract
Cuproptosis represents a novel class of cell death modality different from other regulated cell death pathways. However, the role of genes involved in copper-mediated cell death within the tumor microenvironment of gastric adenocarcinoma remains to be elucidated. This study utilized R programming to classify unprocessed information from TCGA and GEO repositories of individuals with stomach adenocarcinoma. Associations among various patient clusters, clinical factors, immune cell infiltration attributes, and the tumor microenvironment were assessed. Graphical displays were generated to improve the practical utility of copper-dependent cell death gene scores and evaluate patient outcome probabilities. This work sought to examine the links between copper-mediated cell death and molecular traits, immune cell presence in the tumor, patient outcomes, and therapeutic approaches. A copper-dependent cell death gene score was developed to predict patient survival and assess its prognostic value in stomach adenocarcinoma. Results revealed that reduced copper-mediated cell death scores correlated with increased tumor mutations, immune responsiveness, and greater survival rates, while elevated scores were linked to suppressed immunity and enhanced tumor microenvironment signaling. This study additionally determined prognostic factors related to copper-dependent cell death genes in stomach adenocarcinoma, which could elucidate qualities of the tumor surroundings and aid in the development of enhanced immunotherapeutic approaches.
Keywords
cuproptosis; biomarkers; stomach adenocarcinoma; immunotherapy
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[3]AHMAD ALHASKAWI, SOHAIB HASAN ABDULLAH EZZI, YANZHAO DONG, et al. Recent advancements in the diagnosis and treatment of acral melanoma[J]. Journal of Zhejiang University SCIENCE B,2024,25(2):106-122.DOI:10.1631/jzus.B2300221.
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[35]Ardissone A, Ferrera G, Lamantea M E.Phenotyping mitochondrial DNA‐related diseases in childhood: A cohort study of 150 patients[J].European journal of neurology: the official journal of the European Federation of Neurological Societies, 2023, 30(7):2079-2091.DOI:10.1111/ene.15814.
[36]Morganti S, Tolaney S M.Role of Immunotherapy in Early- and Late-Stage Triple-Negative Breast Cancer[J].Hematology/oncology clinics of North America, 2023, 37(1):133-150.DOI:10.1016/j.hoc.2022.08.014.
[37]Jin J, Mou H, Zhou Y,et al.Nomogram for Predicting Survival Post-Immune Therapy in Cholangiocarcinoma Based on Inflammatory Biomarkers:[J].Cancer Control, 2024, 31(9):557-588.DOI:10.1177/10732748241305237.
Mishra R, Quraishi R, Deep R,et al.An Exploratory Case–Control Study for Mitochondrial DNA G10398A in Bipolar I Disorder Patients with a Family History of Affective Disorders[J].Nigerian Postgraduate Medical Journal, 2024, 31(3):234-239.DOI:10.4103/npmj.npmj_119_24.
Copyright © 2025 Jinyuan Li, Huixia Rao, Huanhuan Guo, Wenhong Liao, Sijia Xia, Xinyue Wang, Rongbin Pan, Yongcui Liao, Dacheng Zhu
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